Deposição de gadolínio no sistema nervoso central - revisão sistemática e metanálise

Resumo: Gadolinium based contrast agents (GBCAs) are widely used in magnetic resonance imaging. Initially, it was thought that the only risks associated with these agents would be allergic reactions, similar acute adverse reactions, and nephrogenic systemic fibrosis (NSF).
Recently, evidences for deposition of these agents in the brain has come to light: as high MRI
signal intensity on unenhanced T1-weighted images of dentate nucleus and the globus pallidus.
The aim of this study is to investigate if there is in fact relation between the use of the GBCAs and brain deposition, variation among classes of GBCAs deposition, and the relation in different ages.
The systematic review is being conducted according to the PRISMA. The search for articles in the PubMed and Scopus databases was performed in April, 2018. All the steps are being performed by two reviewers, and in cases of divergences, the opinion of a third reviewer
will be considered.
The initial search led to the identification of 14252 articles.
Primary outcomes included the presence of increased signal intensity within the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images in patients following
administrations of GBCAs.
These research will be the first systemic review with meta-analysis in the subject.

Data de início: 2018-06-12
Prazo (meses): 24

Participantes:

Papel	Nome
Coordenador	Marcos Rosa Júnior